• Molecular Biology
    • School of Agriculture & Biology
    • Credit. 2
    • BI335
    • Enroll
    • CURRENT
    • Fall , 2015
    • 723
    • Course Description:
    • ( Exchange Programme )
    • Molecular biology focuses mainly on nucleic acids and proteins and their interactions within the cell to promote accurate cell growth, division, and development. It is an interesting and ever-changing discipline. This course will emphasize the molecular mechanisms underlying DNA replication, repair, transcription, translation, and gene regulation in different organisms. We will also study the techniques and experiments used to understand these mechanisms. We will take an in-depth look at some rapidly evolving fields, including chromatin structure and function and regulation of gene expression by different types of RNAs.
    • Course Syllabus:
    • After completing the course, students should be able to:
      1. Explain the mechanisms of bacterial and eukaryotic DNA replication, repair, transcription, and translation in general.
      2. Explain in depth the molecular mechanisms behind different modes of gene regulation in prokaryotes and eukaryotes at both pre- and post-transcriptional levels.
      3. Explain how DNA topology and chromatin structure affects the processes of DNA replication and transcription and give examples of DNA and histone modifications and predict how they will affect gene expression.
      4. Provide examples of how homologous recombination, site-specific recombination, and transposition can promote both genome stability and genetic diversity.
      5. Describe how pre-mRNA splicing occurs and explain how alternative splicing generates protein diversity.
      6. Compare and contrast various ways in which gene expression is regulated by small RNAs.
      7. Distinguish between different molecular biology techniques that are used to isolate, separate, and manipulated for specific proteins, nucleic acids, and their interactions. Identify limitations of these techniques.
      8. Identify which experimental techniques are best used to answer what type of questions.
      9. Understand how cell growth and development are regulated at the molecular level.
      10. Interpret and critique data from primary research articles.
    • Schedule:
    • Topics / Credit hours / Teaching methodology / Tasks / Intended learning outcomes / Assessment methods

      1. Introduction / 2 Credit hours / Classroom teaching / Homework / History and application / Discussion and quiz
      2. DNA, Chromosome and DNA Replication / 6 Credit hours / Classroom teaching / Homework / Including nucleic acids structure and properties / Discussion and quiz
      3. Governing Principles of Gene Expression / 4 Credit hours / Classroom teaching / Homework / Regulation of transcriptional initiation / Discussion and quiz
      4. Gene Regulation in Prokaryotes and Eukaryotes / 6 Credit hours / Classroom teaching / Homework / Difference and similarity, examples of regulation / Discussion and quiz
      5. Molecular Interaction Promoting Cell Growth / 4 Credit hours / Classroom teaching / Homework / Oncogene and tumor suppressor gene regulating tumorgenesis / Discussion and quiz
      6. Molecular Interaction Promoting Development / 4 Credit hours / Classroom teaching / Homework / Cascade of regulation during Drosophila embryo development / Discussion and quiz
      7. DNA Technology Advancement / 4 Credit hours / Classroom teaching / Homework / Basic techniques / Discussion and quiz
      8. Protein Technology Advancement / 4 Credit hours / Classroom teaching / Homework / Basic techniques / Discussion and quiz
  • Reading list
  • Other Materials
  • Discussion
  • Homework download/submit
    • Yu Yan
    • Read more
    • Female
    • E-mail:
    • yanyu@sjtu.edu.cn
    • Profile
  • Prerequisite Course:

    Biochemistry and Genetics

  • Textbooks:

    Essentials of Molecular Biology, by George Malacinski and David Freifelder, 3rd or 4th edition
  • Grading:

    60% / Final Exams
    20% / Homework
    20% / Class participation
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