• Advanced Microbiology
    • School of Life Sciences & Biotechnology
    • Credit. 1
    • BI211
    • Enroll
    • WILL BEGIN
    • Fall , 2015
    • 783
    • Course Description:
    • ( Exchange Programme )
    • Some bugs can cause human diseases. Humans develop drugs to control these bad bugs. Bad bugs develop resistance to the drugs so that we need to have new drugs for both old and new bad bugs. We thus have a never-ending arm-race with bad bugs. In this course, we will take several reviews published in past 5 years in Nature Reviews Microbiology on drug resistance in bacteria. The integration of ecology and systems biology in drug resistance management will help us to transform from killing-based strategy to an ecological management system for containing drug resistance.
    • Course Syllabus:
    • After completing the course, students should:
      1. Learn how drugs kill bugs and how and why bugs can have drug resistance;
      2. Know what strategies we can have to slow down the evolving of drug resistance.
      3. Find out that new tools such as genomics and bioinformatics will empower us to develop better drugs.
      4. Learn how to read original articles in microbiology.
      5. Develop critical thinking skills and know how to protect self and family members by using a wise medication strategy for drug resistance.
    • Schedule:
    • Topics / Credit hours / Teaching methodology / Tasks / Intended learning outcomes / Assessment methods

      1.How antibiotics kill bacteria: from targets to networks/2 Credit hours/ Lecture/ Group Discussion/ Class participation
      2.Waves of resistance: Staphylococcus aureus in the antibiotic era/2 Credit hours/ Lecture/ Group Discussion/ Class participation
      3.The antibiotic resistome: the nexus of chemical and genetic diversity/2 Credit hours/ Lecture/ Group Discussion/Class participation
      4.FOCUS ON: Antimicrobial resistance/2 Credit hours/Lecture/Group Discussion/ Class participation
      5.Microbiology in the post-genomic era/2 Credit hours/Lecture/Group Discussion/ Class participation
      6.Genome-scale analyses of health-promoting bacteria: probiogenomics/2 Credit hours /Lecture/ Group Discussion/Class participation
      7.Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens/ 2 Credit hours/Lecture/Group Discussion/Class participation
      8.Characterizing the causative role of the gut microbiota in human metabolic diseases/ 2 Credit hours/ Lecture/Group Discussion/Class participation
  • Reading list
  • Other Materials
  • Discussion
  • Homework download/submit
    • Zhao Liping
    • Read more
    • Male
    • E-mail:
    • lpzhao@sjtu.edu.cn
    • Profile
    • Chen Feng
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    • Male
    • E-mail:
    • cf2001@sjtu.edu.cn
    • Profile
  • Prerequisite Course:

    Microbiology (D)

  • Textbooks:

    1.Nature Reviews Microbiology 8, 423-435 (June 2010)|doi:10.1038/nrmicro2333, How antibiotics kill bacteria: from targets to networks,Michael A. Kohanski1,2, Daniel J. Dwyer1& James J. Collins
    2. Nature Reviews Microbiology 7, 629-641 (September 2009)| doi:10.1038/ nrmicro2200,Waves of resistance: Staphylococcus aureus in the antibiotic era,See also: Correspondence by Justin T. Okano & Sally Blow
  • Grading:

    Paper writing
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